VSEL Research
Dementia and the SONG Laser Protocol
A clinical case study explored the use of the SONG Laser Protocol—a technique combining laser-activated autologous stem cells in platelet-rich plasma (PRP)—for a patient with dementia. Following treatment, the patient showed increased EEG alpha wave activity and reported improved memory and well-being, suggesting potential neurological benefits and supporting further controlled trials
Armenian Cardiac Regeneration Study: Laser-Activated Stem Cell Therapy for End-Stage Heart Failure
A pilot study in Armenia tested laser-activated cord blood stem cells in patients with advanced heart failure. Results showed improved heart function (LVEF) following treatment, supporting further research into this regenerative approach
Harnessing Human VSELs: A New Frontier in Regenerative Medicine
This review highlights the regenerative potential of human Very Small Embryonic-Like (hVSEL) stem cells, emphasizing their pluripotent nature and role in tissue repair. It discusses how SONG-modulated laser activation may enhance hVSEL activity, supporting their use as an autologous, ethical alternative for regenerative medicine.
Modulated Laser Light on hVSEL Stem Cells in Platelet-Rich Plasma
This study found that modulated red laser light (SONG protocol) increases the growth of human VSEL stem cells in platelet-rich plasma, suggesting a potential method to enhance autologous stem cell activity for regenerative therapies.
The SONG Laser Protocol and Multiple System Atrophy–Parkinsonian (MSA-P)
A 2025 case study reports a 66-year-old man with Multiple System Atrophy–Parkinsonian type who received three treatments of SONG Laser–activated autologous VSEL stem cells in PRP. Over three months, he showed notable neurological recovery and complete sacral-ulcer healing without adverse effects. The authors suggest the laser-activated stem-cell therapy may aid neuronal and tissue repair, but emphasize that controlled clinical trials are needed to validate safety and efficacy. The nerve improvement described in the paper was primarily related to the Parkinsonian (neurological) symptoms.
Additional VSEL Research
This paper explores how VSELs and MSCs differ in their roles in repairing damaged reproductive tissues. It argues that while MSCs exert therapeutic effects indirectly (via secreted factors), VSELs act as true tissue-resident stem cells capable of differentiation and regeneration. The authors highlight that VSELs may be a more foundational cell population for tissue repair and discuss challenges in detecting and harnessing them.
Very Small Embryonic-Like Stem Cells (VSELs) – an update and future directions
This review discusses a rare population of stem cells in adult tissues known as very small embryonic-like stem cells (VSELs). It outlines their defining characteristics, possible role in tissue regeneration and maintenance, techniques for identification, and the ongoing debate about their existence and therapeutic potential.
A review of VSEL biology and pluripotency, highlighting their ability to form multiple tissue types and their emerging potential in bone, cartilage, and tendon repair, while noting that further research is needed to confirm clinical applications.
This paper proposes a quantum-mechanical model to explain how modulated red-laser (SONG) light may disrupt the binding of the CXCR4 receptor on hVSEL cells — freeing the receptor from its inhibitor (EPI-X4) — which in turn might trigger stem-cell activation and proliferation in PRP.